The Eyckmans lab is dedicated to advancing the science of tissue repair and regeneration. Our research focuses on understanding how cells interact with their surrounding extracellular matrix (ECM) to drive healing processes. We explore these interactions to uncover new ways of guiding tissues toward regeneration rather than fibrosis (scarring) or chronic wounds. By developing innovative biomaterials and engineering tissue models, we aim to transform the treatment of musculoskeletal injuries, skin wounds, and connective tissue disorders. Our current research interests are:

1. Engineering Biomimetic Models for Tissue Repair: Our first research thrust focuses on engineering biomimetic models that replicate key aspects of tissue repair, particularly the dynamics of the provisional matrix—a temporary structure cells create during wound healing. We’ve developed a wound-on-chip platform that mimics the mechanical and biochemical environment of human tissues, allowing us to study how cells interact with the ECM to promote or impair healing. This model system helps us explore critical processes like wound closure, re-epithelialization, and vascularization, giving us unique insights into why some wounds heal properly while others develop into chronic or fibrotic conditions.

2. Modulating Provisional Matrices to Promote Regeneration: Our second research thrust is centered on the provisional matrix itself—understanding its composition and structure, and finding ways to modulate it for better healing outcomes. By mapping different types of provisional matrices in healthy and diseased states, we can identify the specific ECM components that either promote regeneration or lead to impaired healing. Using advanced gene editing techniques, we are working on ways to engineer fibroblasts and modify ECM properties, aiming to restore proper wound healing even in compromised environments, such as in aging or chronic wounds.

3. Integrative Biomaterials for Tissue Repair: The third thrust of our research involves developing novel biomaterials that integrate seamlessly into healing tissues. Traditional biomaterials often act as passive scaffolds that degrade over time, but we are creating materials that cells can recycle and repurpose as they regenerate new tissue.