Publications

2022

37. Engineering a living cardiac pump on a chip using high-precision fabrication”. Michas C., Çagatay M.K., Nautiyal P., Seidman J.G., Seidman C.E., Agarwal A., Ekinci K., Eyckmans J., White A.E., Chen C.S., Sci Adv. 2022, 8(16)eabm3791 Request PDF

36. Notch1 and Notch3 coordinate for pnricyte-induced stabilization of vasculature. Tefft J.B., Bays J.L., Lammers A., Kim S., Eyckmans J., Chen C.S., Am J Physiol Cell Physiol. 2022 Request PDF

2021

35. Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization. Zhang K., Cloonan P.E., Sundaram S., Liu F., Das S.L., Ewoldt J.K., Bays J.L., Tomp S., Toepfer C.N., Marsiglia J.D.C., Gorham J., Reichart D., Eyckmans J., Seidman J.G., Seidman C.E., Chen C.S., Sci Adv. 2021, 7(42)eabh3995 Request PDF

34. Extracellular matrix alignment directs provisional matrix assembly and 3D fibrous tissue closure. Das, S.L., Bose P., Lejeune M., Reich D., Chen C.S., Eyckmans J., Tissue Eng. 2021, Request PDF

33. Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair. Zhou D.W., Fernández-Yagüe M.A., Holland E.N., García A.F., Castro N.S., O’Neill E.B., Eyckmans J. Chen C.S., Fu J., Schlaepfer D.D., García A.J., Nat Comm. 2021, 12:2359 Request PDF

32. Reconstituting the dynamics of endothelial cells and fibroblasts in wound closure. Tefft J.B., Chen C.S., Eyckmans J., APL Bioeng. 2021, 016102 Request PDF

2020

31. Transient support from fibroblasts is sufficient to drive functional vascularization in engineered tissues. Song H-H., Lammers A., Sundaram S., Rubio L., Chen A.X., Li L., Eyckmans J., Bhatia S.N., Chen C.S., Adv. Func. Mater. 2020, 2003777 Request PDF

2019

30. A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling. Nguyen D-H. T., Lee E., Alimperti S., Norgard R.J., Wong A., LeeJ-K., Eyckmans J., Stanger B.Z., Chen C.S., Sci. Adv. 2019, Aug; 28;5(8) Request PDF

29. Surface and bulk stresses drive morphological changes in fibrous microtissues. Mailand E., Li B., Eyckmans J, Bouklas N., Sakar M.S., Biophys J., 2019, Sep;117(5):975-986 Request PDF

28. Myosin IIA-mediated forces regulate multicellular integrity during vascular sprouting. Yoon C.*, Choi C.*, Stapleton S.*, Mirabella T., Howes C., Dong L., King J., Yang J., Oberai A., Eyckmans J.*, Chen C.S.*, MBoC, 2019;30(16):1974-1984Request PDF

27. A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix. Seeherman H.J., Berasi S.P., Brown C.T., Martinez R.X., Juo Z.S., Jelinsky S., Cain M.J., Grode J., Tumelty K.E., Bohner M., Grinberg O., Orr N., Shoseyov O., Eyckmans J., Chen. C.S., Morales P.R., Wilson C.G., Vanderploeg E.J., Wozney J.M., Sci Trans Med. 2019, Apr;11(489)Request PDF

26. Studies of 3D directed cell migration enabled by direct laser writing of curved wave topography. Cheng D., Jayne R.K., Tamborini A., Eyckmans J.*, White A.E.*, Chen C.S*., Biofabrication 2019, Feb; 11(2):021001Request PDF


2018

25. Effects of geometry on the mechanics and alignment of three dimensional engineered microtissues. Bose P., Eyckmans J., Nguyen T.D., Chen C.S., Reich D.H., ACS Biomaterials. 2019;5(8):3843-3855Request PDF

24. Fabrication and mechanical properties measurements of 3D microtissues for the study of cell-matrix interactions. Bose, P., Huang, C.Y., Eyckmans, J., Chen, C.S., and Reich, D.H., Methods in Molecular Biology: The Surfaceome: Methods and Protocols (2018), eds Boheler KR & Gundry RL (Springer).Request PDF

23. Force generation via b-cardiac myosin, titin, and a-actinin drives cardiac sarcomere assembly from cell-matrix adhesions. Chopra A.*, Kutys M.L.*, Zhang K*, Polacheck W.J., Sheng C.C., Luu R.J., Eyckmans J., Hinson J.T.*, Seidman J.G.*, Seidman C.E.*, Chen C.S.*, Dev Cell. 2018, Jan;44(1):87-96.Request PDF


2017

22. A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Polacheck W.J.*, Kutys M.L.*, Yang J., Eyckmans J., Wu Y., Vasavada H., Hirschi K., Chen C.S., Nature 2017, Dec; 552(7684):258-262.Request PDF

21. Designer biomaterials for mechanobiology, Li L.Q., Eyckmans J.*, Chen C.S.*, Nat. Mat. 2017, Nov;16(12):1164-1168.Request PDF

20. Making bone via nanoscale kicks, Eyckmans J.* and Chen C.S.*, Nat Biomed Eng. 2017, Sept;1:689-690.Request PDF

19) Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N-cadherin balance in mural cell-endothelial cell-regulated barrier function. Alimperti A.*, Mirabella T.*, Bajaj V., Polacheck W., Pirone D.M., Duffield J., Eyckmans J., Assoian R.K., and Chen C.S., Proc Natl Acad Sci USA. 2017 Aug;114(33):8758-8763. Request PDF

18. 3D Culture models of tissues under tension. Eyckmans J.*and Chen C.S.*, J Cell Sci. 2017, Jan; 130(1):63-70. Request PDF


2016

17. Cellular forces drive tissue-scale matrix assembly in fibrous tissue repair. Sakar M.*, Eyckmans J.*, Pieters R., Eberli D., Nelson B.J. and Chen C.S., Nat Comm. 2016 Mar;7:11036 Request PDF


2015

16. Patterning vascular networks in vivo for tissue engineering applications. Chaturvedi, R.R., Stevens K.R., Solorzano R.D., Schwartz R.E., Eyckmans J., Baranski J.D., Stapleton S., Bhatia S.N., and Chen C.S., Tissue Eng Part C. 2015 May;21(5):509-17Request PDF


2014

15. Stem cell differentiation: sticky mechanical memory. Eyckmans J., Chen C.S., Nat Mat. 2014 Jun;13(6):542-543.Request PDF


2013

14. Geometric control of vascular networks to enhance engineered tissue integration and function. Baranski J.*, Chaturvedi R.R.*, Stevens K.R.*, Eyckmans J., Carvahlo B., Solorzano R.D., Yang M.T., Miller J.S., Bhatia S.N., Chen C.S., Proc. Natl. Acad. Sci. U.S.A. 2013 May;110(19):7586-91. Request PDF

13. Targeted osteogenic differentiation in vitro leads to robust ectopic bone formation in vivo. Eyckmans J.*, Roberts S.J.*, Bolander J., Schrooten J., Chen C.S., Luyten F.P., , Biomaterials 2013 Jun;34(19):4612-21. Request PDF


2012

12. Adhesive and mechanical regulation of mesenchymal stem cell differentiation in human bone marrow and periosteum-derived progenitor cells. Eyckmans J.*, Lin L.G.*, Chen C.S., Biology Open.  2012 Nov 15;1(11):1058-1068. Request PDF

11. The effect of activating Fibroblast Growth Factor Receptor 3 mutations on human periosteal cell dynamics. Bolander J., Roberts S.J., Eyckmans J., Geris L., Luyten F.P., J Tissue Sci Eng. 2012 S2:003 doi:10.4172/2157-7552.S2-003Request PDF

10. BMP-2-Induced Signaling and Osteogenesis is Regulated by Cell Shape, RhoA/ROCK, and Cytoskeletal Tension. Wang Y-K., Yu X., Cohen D.M., Wozniak M.A., Yang M.T., Eyckmans J., Chen C.S., Stem Cells Dev. 2012 May 1;21(7):1176-86.Request PDF


2011

9. A hitchhiker’s guide to mechanobiology.Eyckmans J., Boudou T., Yu X., Chen C.S., Dev Cell. 2011 Jul 19;21(1):35-47.Request PDF

8. Does tranexamic acid stabilised fibrin support the osteogenic differentiation of human periosteum derived cells? Demol J., Eyckmans J., Roberts S.J., Luyten F.P., Van Oosterwyck H., Eur Cell Mater. 2011 Mar 22;21:272-85.Request PDF

7. Osteoconductive and bioresorbable composites based on poly(L,L-lactide) and pseudowollastonite: from synthesis and interfacial compatibilization to in vitro bioactivity and in vivo osseointegration studies. Raquez J.M., Barone D.T., Luklinska Z., Persenaire O., Belayew A., Eyckmans J., Schrooten J., Dubois P., Biomacromolecules. 2011 Mar 14;12(3):692-700. Request PDF


2010 and earlier

6.  Effects of MRI Contrast Agents on the Stem Cell Phenotype. Crabbe A., Vandeputte C., Dresselaers T., Ayuso Sacido A., Manuel Garcia Verdugo J., Eyckmans J., Luyten F.P., Van Laere K., Verfaillie C.M., Himmelreich U. Cell Trans. 2010;19(8):919-36.Request PDF

5. A clinically relevant model for osteoinduction: a process requiring calcium phosphate and BMP/Wnt signalling. Eyckmans J., Roberts S.J., Schrooten J., Luyten F.P., J Cell Mol Med. 2010 Jun;14 (6B):1845-56 Request PDF

4. Bone augmentation with autologous periosteal cells and two different calcium phosphate scaffolds under an occlusive titanium membrane. Maréchal M., Eyckmans J., Schrooten J., Schepers E., Luyten F.P., van Steenberghe D., J. Periodontol. 2008 May;79(5):896-904 Request PDF

3. Species specificity of ectopic bone formation by periosteum-derived mesenchymal progenitor cells. Eyckmans J., Luyten F.P., Tissue Eng. 2006 Aug;12(8):2203-13. Request PDF

2. Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis. De Bari C., Dell’Accio F., Vanlauwe J., Eyckmans J., Khan I.M., Archer C.W., Jones E.A., McGonagle D., Mitsiadis T.A., Pitzalis C., and Luyten F.P. Arthritis Rheum. 2006 Apr;54, 1209-1221. Request PDF

1. Efficient lentiviral transduction and improved engraftment of human bone marrow mesenchymal cells. Van Damme A., Thorrez L., Ma L., Vandenburgh H., Eyckmans J., Dell’accio F., De Bari C., Luyten F., Lillicrap D., Collen D., Vandendriessche T., and Chuah M.K. Stem Cells. 2006 Apr; 24(4):896-907 Request PDF